The 80-year-old man died on impact, Police say, when his sedan collided head on with a truck near Reid River.
The 60-year-old male truck driver suffered non-life threatening injuries.
Townsville police say officers continue working today to ascertain the cause of the crash.
It’s believed the sedan, for reasons now under investigation, appears to have crossed the centre line and collided head-on with a heavy vehicle.
Firefighters and Ambulance officers from Townsville and Charters Towers were called to the scene.
Police say a report would be prepared for the coroner.